{"id":10523,"date":"2019-11-05T11:12:06","date_gmt":"2019-11-05T10:12:06","guid":{"rendered":"https:\/\/udic.es\/?p=10523"},"modified":"2019-11-05T11:14:51","modified_gmt":"2019-11-05T10:14:51","slug":"lhospital-general-universitari-de-catalunya-un-referent-en-la-investigacio-sobre-lalzheimer","status":"publish","type":"post","link":"https:\/\/udic.es\/ca\/lhospital-general-universitari-de-catalunya-un-referent-en-la-investigacio-sobre-lalzheimer\/","title":{"rendered":"L\u2019Hospital General Universitari de Catalunya, un referent en la investigaci\u00f3 sobre l\u2019Alzheimer"},"content":{"rendered":"

El seu equip de Neurologia i Neuropsicologia est\u00e0 especialitzat en l’avaluaci\u00f3 de biomarcadors i el diagn\u00f2stic preco\u00e7 de malalties neurodegeneratives.<\/span><\/h2>\n

El Dia Mundial de l\u2019Alzheimer \u00e9s aquest dissabte 21 de setembre, dia en qu\u00e8 cal destacar la import\u00e0ncia del desenvolupament de les investigacions que s\u2019estan duent a terme per combatre aquesta malaltia, que encara no disposa de totes les dades sobre les seves causes.<\/span><\/p>\n

L\u2019Alzheimer \u00e9s una malaltia neurodegenerativa que \u00e9s la primera causa de dem\u00e8ncia, entre el 50 i el 70% de la poblaci\u00f3 mundial. Es calcula que uns 40 milions de persones al m\u00f3n afectades per dem\u00e8ncia s\u00f3n atribu\u00efbles a l\u2019Alzheimer. A Espanya, segons dades de la Societat Espanyola de Neurologia (SEN), hi podria haver unes 800.000 persones amb aquesta patologia.<\/span><\/p>\n

QU\u00c8 ES?<\/span><\/h3>\n

L\u2019edat \u00e9s el principal factor de risc per desenvolupar la malaltia, tot i que no s\u2019ha d\u2019oblidar que el 10% dels casos d\u2019Alzheimer comencen per sota dels 65 anys. La prevalen\u00e7a de la malaltia d\u2019Alzheimer augmenta exponencialment despr\u00e9s dels 65 anys. Afecta el 5 per cent de la poblaci\u00f3 de m\u00e9s de 60 anys, el 20 per cent dels majors de 80 anys i el 30 per cent dels majors de 90 anys.<\/span><\/p>\n

L\u2019envelliment progressiu de la poblaci\u00f3 i l\u2019augment de l\u2019esperan\u00e7a de vida fan que hi hagi una proporci\u00f3 creixent de persones exposades a desenvolupar la malaltia. S\u2019espera que el nombre d\u2019afectats augmenti exponencialment en les pr\u00f2ximes d\u00e8cades, fins i tot arribar\u00e0 a superar els 100 milions per al 2050.<\/span><\/p>\n

\"Fotomontaje<\/p>\n

EXPERI\u00c8NCIA I PROFESSIONALITAT<\/span><\/h3>\n

L\u2019Hospital Universitari General de Catalunya compta amb un equip de Neurologia i Neuropsicologia especialitzat en l\u2019avaluaci\u00f3 de biomarcadors i diagn\u00f2stic preco\u00e7 de la malaltia d\u2019Alzheimer i altres dem\u00e8ncies. M\u00e9s enll\u00e0 de l\u2019avaluaci\u00f3 diagn\u00f2stica, ofereix assessorament terap\u00e8utic, assessorament als cuidadors i seguiment de pacients amb deteriorament cognitiu de causa neurodegenerativa.<\/span><\/p>\n

A m\u00e9s, la Unitat d\u2019Investigaci\u00f3 Cl\u00ednica (UDIC), dirigida pel Dr. Balaguer, t\u00e9 una \u00e0mplia experi\u00e8ncia en la inclusi\u00f3 i el seguiment de pacients amb Alzheimer que desitgin participar en assaigs cl\u00ednics per al desenvolupament de nous tractaments per a la malaltia.<\/span><\/p>\n

EQUIP ESPECIALITZAT<\/span><\/h3>\n

L\u2019equip treballa per corregir els s\u00edmptomes associats i retardar el curs de la malaltia. A m\u00e9s, alguns estudis suggereixen “curar” la malaltia si la hip\u00f2tesi proposada en el judici fos positiva: per exemple, si la hip\u00f2tesi amiloide \u00e9s correcta, les ter\u00e0pies antiamiloides serien “curatives”.<\/span><\/p>\n

QU\u00c8 S\u2019INVESTIGA A L\u2019HUGC?<\/span><\/h3>\n

Assajos cl\u00ednics en totes les etapes de la malaltia d\u2019Alzheimer des de inicial fins a moderada i avan\u00e7ada, aix\u00ed com assaigs sobre s\u00edmptomes espec\u00edfics (al\u00b7lucinacions o deliris).<\/span><\/p>\n

Actualment, hi ha tres tipus d\u2019assaigs actius a l\u2019Hospital Universitari General de Catalunya<\/span><\/p>\n

1- Drogues neuro moduladores.<\/span><\/p>\n

Es tracta d\u2019assajos que tenen com a objectiu millorar els s\u00edmptomes de la p\u00e8rdua de mem\u00f2ria. L’hospital ha realitzat un assaig de fase II, de Boehringer \u2013 Ingelheim (20 pacients) i un de fase I, de Heptares (5 pacients).<\/span><\/p>\n

2- Ter\u00e0pia anti-amiloide.<\/span><\/p>\n

S\u00f3n inhibidors de la formaci\u00f3 d\u2019amiloides anomenats BACE que s\u2019administren per via oral.<\/span><\/p>\n

2 assaigs de fase III, un de Lilly (55 pacients) i un altre d\u2019Eisai (30 pacients).<\/span><\/p>\n

2b-Ter\u00e0pia de reempla\u00e7ament anti-amiloide.<\/span><\/p>\n

PROVA CL\u00cdNICA AMBAR<\/span><\/h3>\n

Tamb\u00e9 ha participat en el desenvolupament de l\u2019assaig cl\u00ednic AMBAR, realitzat tant a l\u2019Hospital Universitari General de Catalunya com a la Fundaci\u00f3 ACE.<\/span><\/p>\n

Aquest assaig pret\u00e9n reduir l\u2019amiloide cerebral i millorar el rendiment cognitiu, mitjan\u00e7ant la plasmaf\u00e8resi i l\u2019intercanvi d\u2019alb\u00famina i \/ o immunoglobulines plasm\u00e0tiques. L\u2019assaig ha mostrat resultats positius en pacients amb Alzheimer en fase moderada.<\/span><\/p>\n

2c- Anticossos monoclonals antiamiloides que persegueixen la destrucci\u00f3 d\u2019amiloide.<\/span><\/p>\n

Administrat per via intravenosa, un assaig de fase II (25 pacients) i un de fase III d\u2019Eisai (ara mateix iniciat); aix\u00ed com 2 assaigs de fase III de Roche (30 pacients en total).<\/span><\/p>\n

DIAGN\u00d3STIC TARD\u00c0<\/span><\/h3>\n

El diagn\u00f2stic tard\u00e0 d\u2019Alzheimer es deu sovint a l\u2019associaci\u00f3 amb dem\u00e8ncia, amb l\u2019estigma social que comporta. Avui dia, se sap que l\u2019Alzheimer \u00e9s un proc\u00e9s continuat, en qu\u00e8 les alteracions a nivell cerebral s\u2019inicien en alguns casos fins i tot d\u00e8cades abans de la presentaci\u00f3 dels primers s\u00edmptomes i on la fase de dem\u00e8ncia \u00e9s nom\u00e9s el final d\u2019aquest proc\u00e9s.<\/span><\/p>\n

Cal conscienciar tant a la societat com al sector sanitari que aquesta realitat augmentaria el diagn\u00f2stic preco\u00e7 i que podria promoure la implementaci\u00f3 de mesures de prevenci\u00f3 i el desenvolupament d\u2019estudis i assaigs cl\u00ednics amb el mateix objectiu.<\/span><\/p>\n

INVESTIGAR L\u2019 ALZHEIMER COM A PRIORITAT<\/span><\/h3>\n

Tot i el coneixement creixent de la hist\u00f2ria natural de la malaltia d\u2019Alzheimer i els aven\u00e7os en el diagn\u00f2stic preco\u00e7 de la malaltia, hi ha hagut poca progressi\u00f3 en el desenvolupament de nous tractaments. Tant els f\u00e0rmacs actuals com alg\u00fan nutrient m\u00e8dic, no m\u00e9s aconsegueixe, en el millor dels casos, lleus millores asimptom\u00e0tiques en l\u2019evoluci\u00f3 de la malat\u00eda.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

El seu equip de Neurologia i Neuropsicologia est\u00e0 especialitzat en l’avaluaci\u00f3 de biomarcadors i el diagn\u00f2stic preco\u00e7 de malalties neurodegeneratives. 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