{"id":10967,"date":"2020-01-17T13:23:20","date_gmt":"2020-01-17T12:23:20","guid":{"rendered":"https:\/\/udic.es\/?p=10967"},"modified":"2021-11-18T09:55:26","modified_gmt":"2021-11-18T08:55:26","slug":"10967","status":"publish","type":"post","link":"https:\/\/udic.es\/ca\/10967\/","title":{"rendered":"El General de Catalunya, primer hospital d\u2019Espanya activat per a l\u2019assaig de la fase I a Parkinson REASON"},"content":{"rendered":"<h3 style=\"text-align: center;\">L&#8217;objectiu principal d&#8217;aquest estudi \u00e9s avaluar la seguretat i la tolerabilitat de dosis \u00faniques i m\u00faltiples de BIIB094 a participants amb malaltia de Parkinson.<\/h3>\n<p class=\"p1\" style=\"text-align: center;\"><span class=\"s1\"><strong>L\u2019Hospital Universitari General de Catalunya<\/strong> \u00e9s el primer centre d\u2019Espanya que ha estat activat per a un nou i particular assaig de fase I a la <strong>malatia de Parkinson (REASON)<\/strong> amb la intenci\u00f3 de cercar la cura de la malaltia. L\u2019assaig, que ja s\u2019ha iniciat als Estats Units, consisteix en l\u2019administraci\u00f3 mitjan\u00e7ant la injecci\u00f3 per via intratecal -espai ple de l\u00edquid entre les fines capes de teixits que envolten el cervell i la <a href=\"http:\/\/medul.la\/\"><span class=\"s2\">m\u00e8dul.la<\/span><\/a> espinal- d\u2019una dosi d\u2019un oligonucle\u00f2tic antisentit, que evita el senyal que activa un gen anomenat LRRK2, conegut com &#8220;la mutaci\u00f3 vasca&#8221; o Parkina 8, amb la idea d&#8217;inhibir la formaci\u00f3 de la prote\u00efna alfa-sinucle\u00efna.<\/span><\/p>\n<p class=\"p1\" style=\"text-align: center;\"><span class=\"s1\">La malaltia de Parkinson, un trastorn neurodegeneratiu de causa desconeguda, que produeix tremolor de rep\u00f2s, lentitud de moviments i rigidesa, s&#8217;origina per un d\u00e8ficit de dopamina a nivell dels ganglis basals i es caracteritza per la pres\u00e8ncia d&#8217;aquesta prote\u00efna an\u00f2mala que \u00e9s la alfa-sinucle\u00efna.<\/span><\/p>\n<h2 class=\"p1\" style=\"text-align: center;\"><span class=\"s1\">Es tracta d\u2019un experiment brillant per a modificar l\u2019evoluci\u00f3 natural del parkinson.<\/span><\/h2>\n<p class=\"p1\" style=\"text-align: center;\"><span class=\"s1\">L\u2019objectiu principal d\u2019aquest estudi \u00e9s avaluar la seguretat i la tolerabilitat de dosis \u00faniques i diverses de BIIB094 que participen amb malaltia de Parkinson. L\u2019objectiu secundari \u00e9s avaluar el perfil farmacocin\u00e8tic (PK) de BIIB094. L\u2019estudi est\u00e0 obert per a participants amb malaltia de Parkinson i amb una pres\u00e8ncia,  verificada o no, de mutacions en el gen de la quinasa 2 rica-repetida en leucina (LRRK2), per\u00f2 tamb\u00e9 per als pacients sense cap mena de mutaci\u00f3 gen\u00e8tica verificada relacionada amb aquesta malaltia, doncs s&#8217;ha relacionat una sobre-expressi\u00f3 d&#8217;aquest gen en tots els pacients amb Parkinson i no solament amb els mutants LRRK2. En aquests \u00faltims pacients s&#8217;evitaria la progressi\u00f3 de la malaltia mentre que els primers pacients podrien arribar a evitar-la.<\/span><\/p>\n<p class=\"p1\" style=\"text-align: center;\"><span class=\"s1\">Per a Ernest Balaguer, director d\u2019investigaci\u00f3 de l\u2019HUGC i responsable de la Unitat d\u2019Investigaci\u00f3 Cl\u00ednica (UDIC) es tracta d\u2019un \u201cexperiment brillant per a modificar l\u2019evoluci\u00f3 natural del parkinson, tant per als pacients que tenen aquesta\u201c mutaci\u00f3 vasca \u201dcom per als que no la tenen, i podria evitar la progressi\u00f3 de la malaltia &#8220;. En <a href=\"http:\/\/www.clinicaltrials.gov\/\"><span class=\"s2\">www.clinicaltrials.gov<\/span><\/a> ja apareix l&#8217;assaig cl\u00ednic i en breu apareixer\u00e0 l&#8217;Hospital Universitari General de Catalunya, aix\u00ed com al cercador d&#8217;assaigs de la Fundaci\u00f3 Michel J Fox.<\/span><\/p>\n<p class=\"p1\" style=\"text-align: center;\"><span class=\"s1\">A l\u2019Hospital s\u2019estan desenvolupant diverses l\u00ednies d\u2019investigaci\u00f3 a trav\u00e9s de la UDIC, cobertes pel doctor Ernest Balaguer. S&#8217;ha de destacar que, d&#8217;els \u00faltims set medicaments anti-Parkinson que han sortit al mercat a Espanya, tots ells han estat evaluats a l&#8217;Hospital General, ja que t\u00e9 una gran experi\u00e8ncia en aquests f\u00e0rmacs.<\/span><\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.consalud.es\/pacientes\/cataluna-hospital-espana-activado-ensayo-fase-parkinson_72988_102.html?fbclid=IwAR2vbD1WYo6kxCQg3-ssO47qflhxIhH4YbeHij6lF6fjlRy56-YI6Wo5z_U\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>M\u00c9S INFO<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>L&#8217;objectiu principal d&#8217;aquest estudi \u00e9s avaluar la seguretat i la tolerabilitat de dosis \u00faniques i m\u00faltiples de BIIB094 a participants amb malaltia de Parkinson. L\u2019Hospital Universitari General de Catalunya \u00e9s el primer centre d\u2019Espanya que ha estat activat per a un nou i particular assaig de fase I a la malatia de Parkinson (REASON) amb&#8230;<\/p>\n","protected":false},"author":2,"featured_media":10959,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[133],"tags":[],"class_list":["post-10967","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-novetats"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>El General de Catalunya, primer hospital d\u2019Espanya activat per a l\u2019assaig de la fase I a Parkinson REASON - UDIC Unitat D&#039;Investigaci\u00f3 Cl\u00ednica<\/title>\n<meta name=\"description\" content=\"L&#039;objectiu principal d&#039;aquest estudi \u00e9s avaluar la seguretat i la tolerabilitat de dosis \u00faniques i m\u00faltiples de BIIB094 a participants amb malaltia de\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/udic.es\/ca\/10967\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"El General de Catalunya, primer hospital d\u2019Espanya activat per a l\u2019assaig de la fase I a Parkinson REASON - 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