{"id":11944,"date":"2021-06-03T10:13:17","date_gmt":"2021-06-03T08:13:17","guid":{"rendered":"https:\/\/udic.es\/?p=11944"},"modified":"2024-02-14T15:36:16","modified_gmt":"2024-02-14T14:36:16","slug":"la-udic-ha-inclos-el-primer-pacient-del-mon-en-un-assaig-clinic-de-fase-i-sobre-lalzheimer","status":"publish","type":"post","link":"https:\/\/udic.es\/en\/la-udic-ha-inclos-el-primer-pacient-del-mon-en-un-assaig-clinic-de-fase-i-sobre-lalzheimer\/","title":{"rendered":"The General University Hospital of Catalonia (HUGC), through the Clinical Research Unit (UDIC), has included the world’s first patient in a phase I clinical trial on Alzheimer’s."},"content":{"rendered":"

This study could improve the efficacy and safety of the products being evaluated to try to modify the progressive course of mild to moderate prodromal Alzheimer\u2019s disease.<\/p>\n

In this research, which is identified with the name Brain shuttle, a solution to the difficulty of access of drugs inside the central nervous system is proposed. It is a technology developed by Roche to increase the penetration of large molecules, such as antibodies, into the brain.<\/p>\n

Specifically, the safety and tolerance at different doses of an antiamyloid monoclonal antibody (gantenerumab) are evaluated with a module that acts as a shuttle to cross the blood-brain barrier and release it into the brain.<\/p>\n

This is key, as one of the main obstacles in the development of new treatments is their ability to cross the blood-brain barrier and reach the brain (due to its large size), unlike the drugs used in these therapies to date.<\/p>\n","protected":false},"excerpt":{"rendered":"

This study could improve the efficacy and safety of the products being evaluated to try to modify the progressive course of mild to moderate prodromal Alzheimer\u2019s disease. In this research, which is identified with the name Brain shuttle, a solution to the difficulty of access of drugs inside the central nervous system is proposed. It…<\/p>\n","protected":false},"author":2,"featured_media":9967,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[129,1],"tags":[],"class_list":["post-11944","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-alzeimer-2","category-uncategorised"],"yoast_head":"\nThe General University Hospital of Catalonia (HUGC), through the Clinical Research Unit (UDIC), has included the world's first patient in a phase I clinical trial on Alzheimer's. - UDIC Unitat D'Investigaci\u00f3 Cl\u00ednica<\/title>\n<meta name=\"description\" content=\"This study could improve the efficacy and safety of the products being evaluated to try to modify the progressive course of mild to moderate prodromal\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/udic.es\/en\/la-udic-ha-inclos-el-primer-pacient-del-mon-en-un-assaig-clinic-de-fase-i-sobre-lalzheimer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The General University Hospital of Catalonia (HUGC), through the Clinical Research Unit (UDIC), has included the world's first patient in a phase I clinical trial on Alzheimer's. - UDIC Unitat D'Investigaci\u00f3 Cl\u00ednica\" \/>\n<meta property=\"og:description\" content=\"This study could improve the efficacy and safety of the products being evaluated to try to modify the progressive course of mild to moderate prodromal\" \/>\n<meta property=\"og:url\" content=\"https:\/\/udic.es\/en\/la-udic-ha-inclos-el-primer-pacient-del-mon-en-un-assaig-clinic-de-fase-i-sobre-lalzheimer\/\" \/>\n<meta property=\"og:site_name\" content=\"UDIC Unitat D'Investigaci\u00f3 Cl\u00ednica\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/UDIC-Unitat-dInvestigaci%c3%b3-Cl%c3%adnica-447149502490430\/\" \/>\n<meta property=\"article:published_time\" content=\"2021-06-03T08:13:17+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-02-14T14:36:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/udic.es\/wp-content\/uploads\/2019\/03\/Blogudic1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1181\" \/>\n\t<meta property=\"og:image:height\" content=\"591\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Tito Surribas\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Tito Surribas\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/udic.es\/en\/la-udic-ha-inclos-el-primer-pacient-del-mon-en-un-assaig-clinic-de-fase-i-sobre-lalzheimer\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/udic.es\/en\/la-udic-ha-inclos-el-primer-pacient-del-mon-en-un-assaig-clinic-de-fase-i-sobre-lalzheimer\/\"},\"author\":{\"name\":\"Tito Surribas\",\"@id\":\"https:\/\/udic.es\/#\/schema\/person\/a8ae8ae960ad58f89663d1d0a2199d1e\"},\"headline\":\"The General University Hospital of Catalonia (HUGC), through the Clinical Research Unit (UDIC), has included the world’s first patient in a phase I clinical trial on Alzheimer’s.\",\"datePublished\":\"2021-06-03T08:13:17+00:00\",\"dateModified\":\"2024-02-14T14:36:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/udic.es\/en\/la-udic-ha-inclos-el-primer-pacient-del-mon-en-un-assaig-clinic-de-fase-i-sobre-lalzheimer\/\"},\"wordCount\":178,\"publisher\":{\"@id\":\"https:\/\/udic.es\/#organization\"},\"image\":{\"@id\":\"https:\/\/udic.es\/en\/la-udic-ha-inclos-el-primer-pacient-del-mon-en-un-assaig-clinic-de-fase-i-sobre-lalzheimer\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/udic.es\/wp-content\/uploads\/2019\/03\/Blogudic1.jpg\",\"articleSection\":[\"Alzeimer\",\"Uncategorised\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/udic.es\/en\/la-udic-ha-inclos-el-primer-pacient-del-mon-en-un-assaig-clinic-de-fase-i-sobre-lalzheimer\/\",\"url\":\"https:\/\/udic.es\/en\/la-udic-ha-inclos-el-primer-pacient-del-mon-en-un-assaig-clinic-de-fase-i-sobre-lalzheimer\/\",\"name\":\"The General University Hospital of Catalonia (HUGC), through the Clinical Research Unit (UDIC), has included the world's first patient in a phase I clinical trial on Alzheimer's. - 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